Kamala Harris accepted her nomination for the vice-presidency contender from Democratic Party.
The running mate with the president nominee Joe Biden delivered her speech on the party convention.
In her speech, she targeted President Donald Trump and called his leadership as a failure.
Joe Biden and her California senator Kamala Harris will face the Donald Trump and Mice Pence for the President and Vice-President role respectively.
The American elections will be held on November 3.
What did Kamala said?
"We're at an inflection point," she said, speaking live from a largely empty hotel ballroom in Mr. Biden's hometown of Wilmington, Delaware.
Attacking Mr. Trump, she continued: "The constant chaos leaves us adrift. Incompetence makes us feel afraid. Callousness makes us feel alone. It's a lot.
"And here's the thing: We can do better and deserve so much more.
"We must elect a president who will bring something different, something better, and do the important work."
Kamala Harris also said that she along with Joe Biden will do every possible thing to revive the country's future after the COVID-19 pandemic and reduce the racial tensions in the United States of America.
"There is no vaccine for racism," she said. "We've got to do the work."
She continued: "Donald Trump's failure has cost lives and livelihoods."
"Right now, we have a president who turns our tragedies into political weapons," she added.
After the speech of Kamala Harris in the party convention, Donald Trump retaliated with his tweet.
"But didn't she call him a racist??? Didn't she say he was incompetent???," Donald Trump wrote in his tweet.
Also on Wednesday, Barack Obama, former US president attacked Donald Trump by accusing his Republican successor of treating the White House like "one more reality show."