Health Issues: A recent research in the Journal of the American Medical Association found that individuals with an extra X or Y chromosome are more likely to have deadly blood clots known as venous thromboembolism (VTE) (JAMA). 9,00,000 Americans are thought to be affected with VTE each year, which frequently results in death.
VTE is frequent with following patients
It involves deep vein thrombosis and pulmonary embolism, and it is a frequent consequence for patients in critical care and those with medical diseases including cancer and Covid-19. Pneumoembolism is a term used to describe a blood clot in the lung, whereas deep vein thrombosis is used to describe a blood clot in a deep vein, typically in the leg.
Supernumerary sex chromosome aneuploidy is the name for the genetic disorder in which an extra X or Y chromosome is present. An attributive term for something existing in excess of the required or typical quantity is supernumerary. An imbalanced chromosomal complement is referred to as aneuploidy when one or more excess or missing chromosomes are present.
Over six lakh people were a part of study
In the study, two patient groups’ genetic and electronic health record data were analysed by the Geisinger Health System, a local healthcare organisation with its main office in Danville, Pennsylvania. 6,42,544 patients signed up for the UK Biobank and the MyCode Community Health Initiative at Geisinger. This is another sizable population study located in the UK. Using a system-wide biobank to preserve blood and other sample types for use in research, particularly genetic research, the MyCode Community Health Initiative is a precision medicine project that enrols patients at Geisinger facilities in Pennsylvania.
According to the authors’ research, one in 500 Geisinger patients have an extra X or Y chromosome in their genome network in addition to the standard two X chromosomes found in females and X and Y chromosomes found in men.
According to the study, the risk of VTE was four to five times greater in those having an extra X or Y chromosome.
The data revealed that Turner syndrome, a condition in which one or both X or Y chromosomes are lost, is not linked to an increased risk of blood clots. The authors came to the conclusion that more investigation is required to fully comprehend this association’s medical significance.
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