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HomeBRAND REVIEWGADGETSWireless smart bandage can cure chronic wounds and improve skin recovery reveals...

Wireless smart bandage can cure chronic wounds and improve skin recovery reveals Study

Wireless smart bandage: Can you envision a smart bandage that heals your wounds quickly? Stanford University researchers have created a wireless smart bandage that can speed up tissue restoration, monitor wound healing, and treat the wound all at the same time. The outcomes of the study were recently published in the journal Nature Biotechnology.

Many people benefit from wireless bandages because some wounds simply do not heal. Furthermore, healing may be hindered by infections, disorders such as diabetes, or reduced immune systems.
Chronic wounds must be healed as soon as possible since they can create worry and despair, and in the worst circumstances, they can be fatal.

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How does the new smart bandage operate?

Prior to Stanford University’s recent research, solutions for healing persistent wounds were scarce. The wireless smart bandage promotes faster wound closure, stimulates new blood flow to wounded tissue, and improves skin regeneration by lowering scar formation significantly.
Using impedance (resistance) or temperature sensors, the wireless circuitry inside the smart bandage can monitor the development of wound healing. If the wound is less healed or an infection is identified, the sensors alert a central processing unit to administer more electrical stimulation across the wound bed. Electrical stimulation will hasten tissue closure and decrease infection. Researchers were able to track sensor data in real time on a smartphone because the bandage incorporates wireless technology.

What makes the new smart bandage unique?

The bandage is made out of an electrical layer that is only 100 micrometres thick. A microcontroller unit (MCU), radio antenna, biosensors, memory, and an electrical stimulator are all part of the electronic layer. It’s the thickness of a single application of latex paint.

The electronics is hidden beneath a brilliantly constructed hydrogel, a rubbery, skin-like material. The hydrogel and circuitry are merged to provide therapeutic electrical stimulation to wounded tissue while also collecting real-time biosensor data.

The polymer in the hydrogel has been carefully engineered by scientists so that it clings securely to the wound surface when needed.

When warmed to a few degrees over body temperature, around 40 degrees Celsius, the hydrogel may be peeled away cleanly and gently without harming the incision.

Electrical stimulation, also known as galvanotaxis, has been found to proactively promote tissue growth and help with tissue repair by accelerating the migration of keratinocytes to wound sites, preventing the formation of biofilms on wound surfaces, and limiting bacterial infections, according to a statement released by the Stanford Wearable Electronics Initiative. The researchers combined this well-studied technology with real-time biosensor data to create a unique biosensor-informed automated therapy method.

Through its biosensing capabilities, which can detect biophysical changes in the local environment, the smart bandage can give a real-time, quick, resilient, and exceptionally accurate means to measure wound conditions.

According to the statement, the smart bandage detects conductivity and temperature changes in the skin while the lesion heals. As wounds heal, electrical impedance rises, while local temperature falls as inflammation fades.

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Why and how does electrical stimulation accelerate wound healing?

The researchers conducted additional studies to better understand why and how electrical stimulation accelerates wound healing. The researchers believe that electrical stimulation stimulates the activation of pro-regenerative genes such as Selenop and Apoe. Selenop is a pro-inflammatory gene that has been linked to pathogen clearance and wound healing. Apoe is a gene that has been proven to promote the growth of muscle and soft tissue.

The study also discovered that electrical stimulation boosted the number of white blood cell populations, specifically monocytes and macrophages, by recruiting more M2 anti-inflammatory macrophages. These macrophages are pro-regenerative and play an important role in the production of extracellular matrix during the proliferative phases of wound healing.

Smart bandage clinical application challenges

While the smart bandage is yet a proof of concept, it is promising. Many problems remain, including raising the device’s size to human scale, resolving long-term data storage issues, and lowering costs. These processes are required before the bandage can be mass-produced.

The scientists could incorporate new sensors that assess pH, metabolites, and biomarkers.

Other barriers to clinical application include hydrogel rejection, in which the skin reacts to the device and creates a suboptimal gel-to-skin mix, and biofouling of the sensors, which can cause irritation.

Nonetheless, the researchers are optimistic that the smart bandage will be useful in healing persistent wounds.

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